Published on: October 11, 2025, at 10:01 AM.

Updated on: October 11, 2025, at 10:01 AM.

• Significant betting activity on Lions vs. Chiefs Over
• Bills need to showcase strength against Falcons, missing key players Oliver and Milano
• Jackson remains sidelined for Ravens

As stated by Joey Feazel, Head of Football at Caesars Sportsbook, there’s considerable betting engagement for the Chiefs facing off against the Lions this Sunday night at Arrowhead Stadium, particularly with a heavy lean on the Lions and the Over (52.5).

Lamar Jackson Unavailable for Ravens

“In contrast, the hype around the Rams and Ravens game hasn’t met early-season expectations,” he conveyed to Casino.org. “This is largely due to Lamar Jackson’s injury; a month ago, it seemed like a marquee matchup, but now it lacks that appeal.”

For reference, during the Thursday night thriller, the Giants, led by QB Jaxson Dart, pulled off a stunning upset against the favored Eagles, winning 34-17. A Caesars Sportsbook customer placed a wager of USD $339,000 on the Giants +7.5 (-113), netting a $300,000 win.

49ers to Start Mac Jones at Quarterback Again

The Lions currently hold a record of 4-1, while the Chiefs sit at 2-3.

“In other news, the Lions-Chiefs game stands as our most bet match of the week, with over 75% of bettors backing the Lions with the spread on the road,” explained Adrian Horton, Senior Director of North American Sport Trading at ESPN BET. “The betting handle has a slightly tighter split at 60/40 in favor of Detroit, pushing the line to +2.5.”

“The Broncos are generating the most interest this week, as they’re our top choice for spread, handling, and Moneyline tickets, aiming to defeat the Jets in London.”

Ed Oliver and Matt Milano Doubtful for Bills

On the props side, Jahmyr Gibbs leads as the top TD scorer by total bets, while Bo Nix’s 1+ Total Passing Touchdowns prop has the highest bets outside of TDs (notably, Nix and his wife just announced they’re expecting their first child).

Turning to DraftKings, Johnny Avello, the Las Vegas bookmaker and Race and Sportsbook director, shared some insights on current betting trends:

Browns vs. Steelers: “A challenging scheduling situation for the Browns; returning from London while the Steelers enjoyed a bye week. The line has moved from 4.5 to 5.5.”

Seahawks Facing Defensive Challenges

Cardinals vs. Colts: “The Cardinals come off a bewildering loss to the Titans. Although [QB Kyler] Murray is listed as probable, the line has shifted to 7 from an opening of 3.5.”

Bengals vs. Packers: “Initially set around a field goal before the season, the line now sits at 14, showcasing how much has changed.”

Lions vs. Chiefs: “The premier game for Sunday night; early bets seem to be favoring the Chiefs, pushing the line to 2.5 from 1.5.”

The Bills, holding a 4-1 record, are set to clash with the Falcons in one of the two Monday Night Football matchups, alongside the Bears at Commanders. The Bills are favored at -225 against the Falcons, who come in at +185. Despite leading the AFC East, the Bills face significant injury uncertainties, with key players TE Dalton Kincaid, LB Matt Milano, DT T.J. Sanders, and DT Ed Oliver all marked as questionable.