Published on: January 10, 2026, 08:38h.
Updated on: January 10, 2026, 08:38h.
- Heavy betting on Philadelphia Eagles during NFL Wild Card Weekend
- Buffalo Bills slightly favored against Jacksonville Jaguars
- Los Angeles Rams significant favorites versus Carolina Panthers
Today marks the kickoff of the thrilling Wild Card Weekend in the NFL. With six exciting matchups taking place this afternoon, as well as on Sunday and Monday night, sportsbooks are particularly focused on the NFC clash featuring the San Francisco 49ers versus the Philadelphia Eagles in Philadelphia.
The Eagles are seeing significant support from bettors.
“Currently, we’ll be rooting for San Francisco this Sunday, as a Philadelphia cover would be a substantial outcome for us this weekend,” stated Adrian Horton, Senior Director, North American Sports Trading at theScore Bet. “The Eagles represent the most wagered spread among the six matchups, prompting us to adjust their line by two points to -5.5.”
Christian Cipollini, Senior Trading Manager at BetMGM, remarked that this year’s NFL playoffs are highly unpredictable.
The NFL playoffs are extremely competitive this season,” he explained. “Any team has a chance at lifting the Lombardi Trophy, and we wouldn’t be surprised by any outcome. The Chargers or Jaguars claiming victory would be ideal for the sportsbook.”
NFC, (5) L.A. Rams at (4) Carolina Panthers (Today, 4:30 p.m. EST, Fox)
The Rams will miss RG Kevin Dotson (ankle) while WR Jordan Whittington (knee), TE Terrance Ferguson (hamstring), and CB Josh Wallace (ankle) face questionable statuses. The Panthers have G Robert Hunt (biceps) and G Chandler Zavala (calf) also listed as questionable.
DraftKings: ML, Rams -600, Panthers +440; Spread, Rams -10 (-115), Panthers +10 (-105); O 45.5 (-115), U 45.5 (-105)
FanDuel: ML, Rams -620, Panthers +460; Spread, Rams -10.5 (-110), Panthers +10.5 (-110); O 46.5 (-104), U 45.5 (-118)
NFC, (7) Green Bay Packers at (2) Chicago Bears (Today, 8 p.m. EST, Prime)
The Packers will be without WR Dontayvion Wicks (concussion). QB Malik Willis (right shoulder/hamstring), OL Zach Tom (back/knee), DL Warren Brinson (foot), LB Nick Niemann (pectoral) and S Javon Bullard (knee) are tagged as questionable.
For the Bears, DL Joe Tryon-Shoyinka (concussion), LB Amen Ogbongbemiga (concussion), and DB Chauncey Gardner-Johnson (concussion) are out. OL Braxton Jones (knee) and DB Kyler Gordon (groin) are also dubious.
DraftKings: ML, Packers -130, Bears +110; Spread, Packers -1.5 (-115), Bears +1.5 (-105); O 44.5 (-112), U 44.5 (-108)
FanDuel: ML, Packers -126, Bears +108; Spread, Packers -1.5 (-114), Bears +1.5 (-106); O 44.5 (-115), U 44.5 (-105)
AFC, (6) Buffalo Bills at (3) Jacksonville Jaguars (Sunday, 1 p.m. EST, CBS)
This matchup is poised to be the highlight of the weekend. Bills QB Josh Allen aims for a Super Bowl title, meaning immense pressure rests on his shoulders. Allen is the current MVP, though Jaguars’ QB Trevor Lawrence is on fire and arguably the league’s hottest quarterback right now.
The Bills are coping with a slew of injuries, with LB Terrel Bernard (calf), CB Maxwell Hairston (ankle), and S Damar Hamlin (pectoral) unavailable. RB Ty Johnson (ankle), WR Josh Palmer (ankle), LB Shaq Thompson (neck), and K Matt Prater (right quad) bear questionable statuses. This morning, the Jaguars identified LT Cole Van Lanen (knee) as questionable.
Where is the betting public placing their bets? DraftKings’ Sportsbook Director Johnny Avello indicated to ESPN that this game is witnessing significant balanced action.
DraftKings: ML, Bills -105, Jaguars -115; Spread, Bills +1.5 (-118), Jaguars -1.5 (-102); O 51.5 (-112), U 51.5 (-108)
FanDuel: ML, Bills -108, Jaguars -108; Spread, Bills -1.5 (+100), Jaguars +1.5 (-122); O 51.5 (-115), U 51.5 (-105)
NFC, (6) San Francisco 49ers at (3) Philadelphia Eagles (Sunday, 4:30 p.m. EST, Fox)
In terms of injuries, the 49ers might be without WR Jacob Cowing (hamstring), DE Keion White (groin/hamstring), LB Luke Gifford (quadricep), LB Dee Winters (ankle), CB Renardo Green (ankle), WR Ricky Pearsall (knee/ankle), and OT Trent Williams (hamstring) as questionable. Meanwhile, the Eagles have RT Lane Johnson (foot), OL Brett Toth (concussion), and LB Azeez Ojulari (hamstring) possibly sidelined.
DraftKings: ML, 49ers +215, Eagles -265; Spread, 49ers +6 (-112), Eagles -6 (-108); O 44.5 (-108), U 44.5 (-112)
FanDuel: ML, 49ers +210, Eagles -255; Spread, 49ers +5.5 (-108), Eagles -5.5 (-112); O 44.5 (-105), U 44.5 (-115)
AFC, (7) Los Angeles Chargers at (2) New England Patriots (Sunday, 8 p.m. EST, NBC)
The Chargers are dealing with injuries to WR KeAndre Lambert-Smith (hamstring) and S Kendall Williamson (ankle), both ruled out. RB Omarion Hampton (ankle), TE Tucker Fisk (ankle), RT Austin Deculus (oblique), OLB Bud Dupree (hamstring), LB Del’Shawn Phillips (hamstring), and S Elijah Molden (hamstring) are questionable.
For the Patriots, DL Khyiris Tonga (foot) is out, while WR Kayshon Boutte (hamstring), OT Thayer Munford Jr. (knee), and LB Harold Landry (knee) are listed as questionable.
DraftKings: ML, Chargers +160, Patriots -192; Spread, Chargers +3.5 (-112), Patriots -3.5 (-108); O 45.5 (-115), U 45.5 (-105)
FanDuel: ML, Chargers +164, Patriots -196; Spread, Chargers +3.5 (-110), Patriots -3.5 (-110); O 45.5 (-114), U 45.5 (-106)
AFC, (5) Houston Texans at (4) Pittsburgh Steelers (Monday, 8:15 p.m. EST, ESPN/ABC)
Steelers TE Jonnu Smith (glute) is listed as questionable. The Texans have OT Trent Brown (ankle/knee), CB Kamari Lassiter (ankle/knee), DE Denico Autry (knee), RB Jawhar Jordan (ankle), and OT Tytus Howard as questionable as well.
DraftKings: ML, Texans -155, Steelers +130; Spread, Texans -3 (-102), Steelers +3 (-118); O 38.5 (-105), U 38.5 (-115)
FanDuel: ML, Texans -158, Steelers +134; Spread, Texans -3 (-105), Steelers +3 (-115); O 38.5 (-105), U 38.5 (-115)
Most Bet Games
According to BetMGM, the most popular games by ticket count are Packers at Bears, Bills at Jaguars, and Rams at Panthers. The most bet spreads in ticket counts are the Patriots (-3.5), Bears (+1), and Texans (-3). In terms of handle, the most bet spreads are Chargers (+3.5), Eagles (-5), and Packers (-1).
In total betting, the most favored bets in tickets are on the 49ers at Eagles (under 44.5), Packers at Bears (under 44.5), and Rams at Panthers (under 46).
The leading props receiving bets today include Luke Musgrave (GB) Under 2.5 Receptions -130, James Cook (BUF) Under 80.5 Rushing yards -140, Dalton Kincaid (BUF) Over 39.5 Receiving yards -110, Quentin Johnston (LAC) Under 39.5 Receiving yards -115, and Jauan Jennings (SF) Over 3.5 Receptions -140. Most wagered for anytime touchdown scorer is Puka Nacua (LAR) at -130.